San Francisco 49ers Roster 2025 Full Depth Chart, Star Players & Draft Picks

You feel it too, right? That unmistakable 49ers energy heading into 2025. It’s not just about a team with Super Bowl dreams — it’s about grit, legacy, and a locker room full of stars and sleepers.

From Brock Purdy’s rise to the battle-hardened defense led by Nick Bosa, here’s your ultimate guide to the Niners roster — built for die-hard fans and fantasy football managers alike.

Quarterbacks

• Brock Purdy – Still the guy. Efficient, cool under pressure, and proving he’s more than a one-season wonder.
• Sam Darnold – Reliable backup, especially with playoff experience.
• Rookie QB (2025) – Developmental depth for future planning.

Running Backs

• Christian McCaffrey – Still elite. Still a PPR king. Still a matchup nightmare.
• Elijah Mitchell – Trusted second option. Solid goal-line work.
• Jordan Mason – Depth with burst — and a sleeper stash in dynasty leagues.

Wide Receivers

• Deebo Samuel – The heartbeat. WR? RB? Doesn’t matter — he’s explosive everywhere.
• Brandon Aiyuk – Sharpened his routes, leveled up his game — WR1-caliber year ahead.
• Jauan Jennings – The clutch third-down guy.
• Rookie WR (2025) – Depth and development.

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Tight Ends

• George Kittle – The people’s tight end. Dominant blocker + elite YAC machine.
• Charlie Woerner – Primarily a blocking TE, but offers rotational support.

Offensive Line

• LT: Trent Williams – The ageless anchor.
• LG: Aaron Banks
• C: Jake Brendel
• RG: Jon Feliciano
• RT: Colton McKivitz

With Williams at the helm, this line stays aggressive and mobile — just how Kyle Shanahan likes it.

Defense: The Gold Standard

• DL: Nick Bosa, Javon Hargrave
• LB: Fred Warner, Dre Greenlaw
• CB: Charvarius Ward, Deommodore Lenoir
• S: Talanoa Hufanga, Ji’Ayir Brown

This defense doesn’t just show up — it imposes its will. Expect sacks, picks, and points.

Fantasy Football Takeaways

• Start Every Week: Christian McCaffrey, George Kittle, 49ers DST
• Sleepers: Elijah Mitchell (bye week fill-in), Jauan Jennings (deep leagues)
• Monitor: Aiyuk’s WR1 breakout, and Deebo’s hybrid usage

FAQ – San Francisco 49ers Roster 2025

Who is the 49ers’ starting QB in 2025?

Brock Purdy continues to lead the team after an impressive 2024 campaign and strong offseason development.

Is Christian McCaffrey still the RB1?

Yes. He’s not only the 49ers’ RB1 — he’s a top-3 fantasy pick league-wide in most formats.

Who are the 49ers’ top wide receivers?

Deebo Samuel and Brandon Aiyuk headline the WR room, with Jennings contributing in clutch moments.

How good is the 49ers defense?

Elite. With Bosa, Warner, and Hufanga, the Niners boast one of the best all-around defenses in the league.

Any rookies to watch?

Watch for the new rookie WR or CB to push into the rotation, and for Ji’Ayir Brown to take the next step at safety.